The ClinicalTrials.gov PRS Beta Will Soon Become the Primary Website for Protocol Registration

On August 28, 2024, the Protocol Registration and Results System (PRS) Beta will become the primary website for protocol registration and management of your list of study records. New features of the Modernized PRS website include:

• An enhanced, user-friendly interface with a fresh color scheme, larger fonts, and clearly identifiable sections and labels.
• Improved navigation between sections and modules of the study record using tabs at the top of the page and a left-hand menu.
• Accessible on-screen guidance and slide-out drawer help content with relevant data element definitions.
• A redesigned Record List that allows you to select columns, to customize the view, to save your customized view, and to export all columns or only the displayed columns to .xlsx or .csv. PRS Administrators can use the new Record List to access and customize the additional columns that make up the planning and public site views.

In addition, data submitters can use the modernized Record Summary page to view a summary of the quality-assurance/quality-control review comments as well as access the comments directly in the relevant protocol registration modules.

These changes are currently available in the modernized PRS Test. To learn more about these and other new features of the Modernized PRS prior to the transition, log into PRS Test.

After the Modernized PRS becomes the primary website, users can seamlessly transition to the Classic PRS to manage some of their records and to enter study results. By default, records containing only the Protocol Section will open in the Modernized PRS. Some functions of the Classic PRS are still being refined within the Modernized PRS as development continues. However, you can easily transition between the classic and modernized websites. For example, to correct certain validation errors, you may have to move from the Modernized PRS to the Classic PRS website. Save your changes in one website before moving to the other. Once saved, data entered in one website will be available in the other.

Figure 1: View of the Modernized PRS Record List with record management drop-down, which links users to the Classic PRS.

Functions not yet available in the Modernized PRS such as uploading a record and records with Results, Delayed Results, and Study Documents will open in the Classic PRS (Figure 1) directly from the modernized website. These sections are still under development and will be available in the modernized website in the future. Similarly, certain links—such as those used to manage accounts and access certain help materials—will take users back to the Classic PRS until these items are available on the modernized website.

Figure 2: The Modernized PRS Record Summary includes a link to view the same record in the classic website in the upper right corner. The yellow Feedback button in the lower right corner is available throughout the website.

The Modernized PRS website will continue to be expanded and improved, and to ensure an optimal user experience, your feedback is essential. Please click the yellow Feedback button in the lower right corner of the screen (Figure 2) to let us know what you think of the Modernized PRS. More information about the transition to the Modernized PRS can be found in the Modernization Transition Top Questions. For registration and results submission questions, please email us at register@clinicaltrials.gov.